Zolpidem tartrate

Insomnia (short-term treatment)

5–10 mg at night

Molecular weight : 764.9

%Protein binding : 92.5

%Excreted unchanged in urine : Negligible (56% as active metabolites)

Volume of distribution (L/kg) : 0.34–0.54 (depends on age)

half-life – normal/ESRD (hrs) : Average: 2.4/ Increased

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD : Not dialysed. Dose as in normal renal function

HD : Not dialysed. Dose as in normal renal function

HDF/high flux : Unknown dialysability. Dose as in normal renal function

CAV/VVHD : Not dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Antibacterials: metabolism accelerated by rifampicin

Antipsychotics: enhanced sedative effects

Antivirals: concentration increased by ritonavir (risk of extreme sedation and respiratory depression) – avoid concomitant use

–

Oral

–

–

First pass metabolism by liver is 35% Clearance is reduced in renal impairment .